Functionalized nucleoside 5'-triphosphates for in vitro selection of new catalytic ribonucleic acids |
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| Authors: | Matulic-Adamic J Daniher A T Karpeisky A Haeberli P Sweedler D Beigelman L |
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| Affiliation: | Department of Chemistry & Biochemistry, Ribozyme Pharmaceuticals, Inc., Boulder, CO 80301, USA. |
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| Abstract: | A series of novel 2'-modified nucleoside 5'-triphosphates was synthesized. The amino, imidazole, and carboxylate functionalities were attached to the 5-position of pyrimidine base of these molecules through alkynyl and alkyl spacers, respectively. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates. |
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