The DD-carboxypeptidase activity encoded by pbp4B is not essential for the cell growth of Escherichia coli |
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Authors: | Daniel Vega Juan A Ayala |
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Institution: | (1) Centro de Biología Molecular “Severo Ochoa” CSIC-UAM, Campus de Cantoblanco, 28049 Madrid, Spain |
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Abstract: | The gene (pbp4B) encoding a putative DD-carboxypeptidase has been deleted in Escherichia
coli and it is shown to be not essential for cell division. Disruption of the gene in a genetic background where all putative
activities of DD-carboxypeptidases and/or DD-endopeptidases had been eliminated indicates that these activities are not required
for cell growth in enterobacteria. The penicillin-binding capacity and a low DD-carboxypeptidase activity of PBP4B are demonstrated.
Electronic Supplementary Material Supplementary material is available for this article at and is accessible for authorized users. |
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Keywords: | Penicillin-binding proteins DD-carboxypeptidase Cell division Escherichia coli |
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