Phenotypic effect of mutations in evolving populations of RNA molecules |
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Authors: | Michael Stich Ester Lázaro Susanna C Manrubia |
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Institution: | 1.Centro de Astrobiología (INTA-CSIC),Madrid,Spain |
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Abstract: | Background The secondary structure of folded RNA sequences is a good model to map phenotype onto genotype, as represented by the RNA
sequence. Computational studies of the evolution of ensembles of RNA molecules towards target secondary structures yield valuable
clues to the mechanisms behind adaptation of complex populations. The relationship between the space of sequences and structures,
the organization of RNA ensembles at mutation-selection equilibrium, the time of adaptation as a function of the population
parameters, the presence of collective effects in quasispecies, or the optimal mutation rates to promote adaptation all are
issues that can be explored within this framework. |
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Keywords: | |
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