Individual fates of mesenchymal stem cells <Emphasis Type="Italic">in vitro</Emphasis> |
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| Authors: | Axel Krinner Martin Hoffmann Markus Loeffler Dirk Drasdo Joerg Galle |
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| Institution: | (1) Interdisciplinary Centre for Bioinformatics, University of Leipzig, Haertelstr. 16-18, 04107 Leipzig, Germany;(2) Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstr. 16-18, 04107 Leipzig, Germany;(3) French National Institute for Research in Computer Science and Control, Domaine de Voluceau-Rocquencourt, B.P. 105, 8153 Le Chesnay Cedex, France |
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| Abstract: | Background
In vitro cultivated stem cell populations are in general heterogeneous with respect to their expression of differentiation markers.
In hematopoietic progenitor populations, this heterogeneity has been shown to regenerate within days from isolated subpopulations
defined by high or low marker expression. This kind of plasticity has been suggested to be a fundamental feature of mesenchymal
stem cells (MSCs) as well. Here, we study MSC plasticity on the level of individual cells applying a multi-scale computer
model that is based on the concept of noise-driven stem cell differentiation. |
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