Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage |
| |
Authors: | Samuel García Myriam Liz Juan J Gómez-Reino Carmen Conde |
| |
Affiliation: | 1.Research Laboratory and Rheumatology Unit,Hospital Clínico Universitario,Santiago de Compostela,Spain;2.Department of Medicine,University of Santiago de Compostela,Santiago de Compostela,Spain |
| |
Abstract: | Introduction Synovial hyperplasia is a main feature of rheumatoid arthritis pathology that leads to cartilage and bone damage in the inflamed joints. Impaired apoptosis of resident synoviocytes is pivotal in this process. Apoptosis resistance seems to involve defects in the extrinsic and intrinsic apoptotic pathways. The aim of this study was to investigate the association of PI3Kinase/Akt and the mitochondrial apoptotic pathway in the resistance of rheumatoid arthritis (RA) fibroblast like synovial cells (FLS) to Fas-mediated apoptosis. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |