Association between polymorphisms of Myf5 and POU1F1 genes with growth and carcass traits in Hanwoo (Korean cattle) |
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Authors: | Jiyeon Seong Jae Don Oh Il Cheong Cheong Kun Woo Lee Hak Kyo Lee Dong Sang Suh Gwang Joo Jeon Kyung Do Park Hong Sik Kong |
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Institution: | 2. Genomic Informatics Center, Hankyong National University, Anseong, 456-749, Korea 3. Department of Genetic Engineering, Sungkyunkwan University, Suwon, 440-746, Korea 1. Genomic Informatics Center, Research Institute for the Far East Asian Bio-Resources, Hankyong National University, Anseong, 456-749, Korea
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Abstract: | Myogenic factor 5 (Myf5) and POU class 1 homeobox 1 (POU1F1) genes play important roles in growth and development of mammals. Bovine Myf5 and POU1F1 were characterized to detect genetic variation at these loci and to replace them to economic traits in 367 cattle representing Hanwoo (325) and Angus (37). Two single nucleotide polymorphisms (SNPs) were identified in intron 2 (A1948G SNP) of Myf5 and exon 6 (A15635G SNP) of POU1F1 by sequence analyses of genomic DNA. Statistical analysis indicated that the Myf5 polymorphisms significantly (0.05) associated backfat thickness and live weight at 6-months-of-age and that POU1F1 polymorphisms significantly influenced carcass weight and live weight at 24-month of age, and backfat thickness. The interaction between Myf5 and POU1F1 was significant on carcass weight, M. longissimus dorsi area, backfat thickness and marbling score. The results implicate Myf5 and POU1F1 as candidate genes of growth and carcass traits, and suggest that the interaction between Myf5 and POU1F1 strongly affect growth and carcass traits in cattle. |
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