Micro-environment effect on the structure of synthetic substrates of thermolysin |
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| Authors: | Sylvie Baltora-Rosset, Danielle Marty, Franç ois-Yves Dupradeau, Emmanuel Pauthe, Vé ronique Larreta-Garde, Gilles Gacel Jean-Pierre Monti |
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| Affiliation: | (1) Groupe de Recherche des Biomolécules: Micro-environnement et Métabolisme, Faculté de Pharmacie, 1 rue des Louvels, F-80037 Amiens Cedex 1, France;(2) Département de Biologie, Université Cergy-Pontoise, F-95302 Cergy-Pontoise Cedex, France |
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| Abstract: | The conformations of thermolysin synthetic substrates inH2O/D2O (9/1) and glycerol-d5 (5 M) are investigated using two-dimensional nuclearmagnetic resonance spectroscopy and molecular modeling. The structuresobtained from molecular modeling and NMR studies are compared. Comparisonsof these structures with bound inhibitor in the active site of thermolysinare also discussed. |
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| Keywords: | Molecular modeling NMR Peptides |
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