Carnosine as a potential scavenger of oxidants generated by stimulated neutrophils |
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| Authors: | B P Sharonov,S N Govorova NJu Y" >Lyzlova |
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| Affiliation: | All Union Research Institute of Highly Pure Biopreparations, Leningrad, USSR. |
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| Abstract: | Luminol-dependent chemiluminescence of PMA-stimulated human neutrophils decrease more than by 50% in the presence of physiological concentrations of carnosine (20 mM). This inhibition is the result of carnosine ability to scavenge hypochlorite (OCl-), since carnosine exerts a similar effect on chemiluminescence produced by myeloperoxidase-H2O2-Cl- and OCl(-)-H2O2 systems. The previously undocumented property of this dipeptide to scavenge active oxygen species requires further experiments. |
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