Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains |
| |
| Authors: | Dankwardt Sharon M Abbot Sarah C Broka Chris A Martin Robert L Chan Christine S Springman Eric B Van Wart Harold E Walker Keith A M |
| |
| Affiliation: | Roche Bioscience, Inflammatory and Viral Diseases Unit, 3401 Hillview Avenue, Palo Alto, CA 94304, USA. sharon.dankwardt@roche.com |
| |
| Abstract: | Optimization of the amino acid side chain and the N-alkyl group of the sulfonamide of amino acid derived sulfonamide hydroxamates is discussed. The solid-phase synthesis of these potent inhibitors of procollagen C-proteinase (PCP) is presented. In addition, novel carboxylic acid sulfonamides were discovered to be PCP inhibitors. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
