Primate evolution of a dispersed human repetitive DNA sequence |
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| Authors: | Steve J Funderburk Ivana Klisak Martha Liao Law Nancy Ma Kathy Neiswanger Robert S Sparkes |
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| Institution: | (1) Department of Psychiatry, Mental Retardation Research Center, USA;(2) Department of Medicine and Pediatrics, UCLA School of Medicine, UCLA Center for the Health Sciences, 90024 Los Angeles, CA, USA;(3) Eleanor Roosevelt Institute for Cancer Research and Department of Pediatrics, University of Colorado Health Sciences Center, 80206 Denver, CO, USA;(4) New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772 Southborough, MA, USA;(5) Department of Anthropology, UCLA, 90024 Los Angeles, CA, USA |
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| Abstract: | A dispersed middle repetitive DNA sequence isolated originally from human chromosome 12 did not show homology with rodent DNA under standard conditions of Southern DNA blot analysis. The evolutionary relationship of this human repetitive DNA to that of other primates was investigated using three hybridization methods: DNA dot blot, Southern DNA blot analysis, and chromosome in situ hybridization. Homology with the human repetitive DNA was found throughout the suborder Anthropoidea, in fourteen ape and New and Old World monkey species. In addition, the human pattern of hybridization to noncentromeric regions of all chromosomes was seen. No hybridization by any of the three techniques was found in five species of the suborder Prosimii. The phenomenon of marked differences in sequence homology and copy number of dispersed repetitive DNA from closely related species has been observed in protozoans (Plasmodia), Drosophila, sea urchins, mice and the great apes (Hominoidea). We report here a similar phenomenon that may have occurred at an early stage in primate evolution. |
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