Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization. |
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| Authors: | P Gmez-Puertas F Rodríguez J M Oviedo F Ramiro-Ibez F Ruiz-Gonzalvo C Alonso and J M Escribano |
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| Institution: | P Gómez-Puertas, F Rodríguez, J M Oviedo, F Ramiro-Ibáñez, F Ruiz-Gonzalvo, C Alonso, and J M Escribano |
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| Abstract: | African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analysis of the neutralization mechanisms mediated by the different viral proteins showed that antibodies to proteins p72 and p54 are involved in the inhibition of a first step of the replication cycle related to virus attachment, while antibodies to protein p30 are implicated in the inhibition of virus internalization. |
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