A new anti-tubulin agent containing the benzo[b]thiophene ring system. |
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| Authors: | K G Pinney A D Bounds K M Dingeman V P Mocharla G R Pettit R Bai E Hamel |
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| Affiliation: | Department of Chemistry, Baylor University, Waco, TX 76798-7348, USA. |
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| Abstract: | A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6-methoxybe nzo[b]thiophene 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines. |
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