Synthesis, cytotoxicity, and structure-activity relationship (SAR) studies of andrographolide analogues as anti-cancer agent |
| |
Authors: | Das Bimolendu Chowdhury Chinmay Kumar Deepak Sen Rupashree Roy Rajneeta Das Padma Chatterjee Mitali |
| |
Affiliation: | Indian Institute of Chemical Biology (CSIR), Kolkata, India. |
| |
Abstract: | A series of analogues of andrographolide, prepared through chemo-selective functionalization at C14 hydroxy, have been evaluated for in vitro cytotoxicities against human leukemic cell lines. Two of the analogues (6a, 9b) exhibited significant potency. Preliminary studies on structure-activity relationship (SAR) revealed that the α-alkylidene-γ-butyrolactone moiety of andrographolide played a major role in the activity profile. The structures of the analogues were established through spectroscopic and analytical data. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|