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A guide to analysis of mouse energy metabolism |
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| Authors: | Tschöp Matthias H Speakman John R Arch Jonathan R S Auwerx Johan Brüning Jens C Chan Lawrence Eckel Robert H Farese Robert V Galgani Jose E Hambly Catherine Herman Mark A Horvath Tamas L Kahn Barbara B Kozma Sara C Maratos-Flier Eleftheria Müller Timo D Münzberg Heike Pfluger Paul T Plum Leona Reitman Marc L Rahmouni Kamal Shulman Gerald I Thomas George Kahn C Ronald Ravussin Eric |
| Affiliation: | Institute for Diabetes and Obesity, Helmholz Centre Munich, Department of Medicine, Technical University of Munich, Munich, Germany. |
| Abstract: | We present a consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistical analysis thereof. We hope this guide will facilitate comparisons across studies and minimize spurious interpretations of data. We recommend that division of energy expenditure data by either body weight or lean body weight and that presentation of group effects as histograms should be replaced by plotting individual data and analyzing both group and body-composition effects using analysis of covariance (ANCOVA). |
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