Equine herpesvirus type 1-mediated oncolysis of human glioblastoma multiforme cells |
| |
Authors: | Courchesne Michael J White Maria C Stanfield Brent A Frampton Arthur R |
| |
Institution: | Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, North Carolina, USA. |
| |
Abstract: | The cytolytic animal virus equine herpesvirus type 1 (EHV-1) was evaluated for its oncolytic potential against five human glioblastoma cell lines. EHV-1 productively infected four of these cell lines, and the degree of infection was positively correlated with glioma cell death. No human major histocompatibility complex class 1 (MHC-I) was detected in the resistant glioma line, while infection of the susceptible glioma cell lines, which expressed human MHC-I, were blocked with antibody to MHC-I, indicating that human MHC-I acts as an EHV-1 entry receptor on glioma cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|