Inhibition of guanylate cyclase and cyclic GMP phosphodiesterase by cholera toxin. |
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| Authors: | H C Kiefer R Atlas D Moldan H S Kantor |
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| Affiliation: | Department of Biochemistry Northwestern University Medical and Dental Schools, Chicago, Ill. 60011 USA;Division of Infectious Disease, Department of Medicine, Chicago Medical School, V. A. Hospital, Downey, Ill. 60064 USA |
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| Abstract: | Results of cholera toxin exposure in rabbit small intestinal epithelial cells, following 4 to 6 hours of incubation, indicate that there is simultaneous dose-dependent activation of adenylate cyclase and deactivation of guanylate cyclase. In addition, cyclic GMP phosphodiesterase activity is repressed. These data indicate that cholera toxin interacts with a binding site of dissociation constant Kd=3.8±1.3 × 10?9M to produce multiple coordinated events in the cells. |
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