2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A1, A2A and A3 receptor subtypes |
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| Authors: | Wanner M J Von Frijtag Drabbe Künzel J K Ijzerman A P Koomen G J |
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| Affiliation: | Laboratory of Organic Chemistry, Institute of Molecular Chemistry, University of Amsterdam, The Netherlands. |
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| Abstract: | The influence of nitro substituents on the properties of adenosine and 1-deazaadenosine was studied. Combination of a nitro group at the 2-position with several N6 substituents such as cyclopentyl and m-iodobenzyl gave a series of analogues with good adenosine receptor affinity, showing directable selectivity for the A1, A2A and A3 adenosine receptor subtypes. |
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