Gene-environment interactions in psychiatry: joining forces with neuroscience |
| |
Authors: | Caspi Avshalom Moffitt Terrie E |
| |
Institution: | Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, P0 Box 80 De Crespigny Park, London SE5 8AF, UK. a.caspi@iop.kcl.ac.uk |
| |
Abstract: | Gene-environment interaction research in psychiatry is new, and is a natural ally of neuroscience. Mental disorders have known environmental causes, but there is heterogeneity in the response to each causal factor, which gene-environment findings attribute to genetic differences at the DNA sequence level. Such findings come from epidemiology, an ideal branch of science for showing that a gene-environment interactions exist in nature and affect a significant fraction of disease cases. The complementary discipline of epidemiology, experimental neuroscience, fuels gene-environment hypotheses and investigates underlying neural mechanisms. This article discusses opportunities and challenges in the collaboration between psychiatry, epidemiology and neuroscience in studying gene-environment interactions. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|