Effect of Electroconvulsive Shock on Muscarinic Cholinergic Receptors in Rat Cerebral Cortex and Hippocampus |
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| Authors: | Bernard Lerer&dagger ,Michael Stanley,&dagger ,Sà ndra Demetriou,&dagger ,Samuel Gershon&dagger |
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| Affiliation: | Jerusalem Mental Health Center, Jerusalem, Israel;Departments of Psychiatry and Pharmacology, Wayne State University and Lafayette Clinic, Detroit, Michigan, U.S.A. |
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| Abstract: | Abstract: Single electroconvulsive shock (ECS) induced no change in [3H]quinuclidinyl benzilate ([3H]QNB) binding to muscarinic cholinergic receptors in rat cortex and hippocampus. ECS administered once daily for 7 days induced a significant reduction in [3H]QNB binding in both brain areas. Concurrent ECS reversed the significant increase in cortical [3H]QNB binding induced by chronic atropine administration. These findings may have relevance to the antidepressant or amnestic effects of electroconvulsive therapy. |
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| Keywords: | Electroconvulsive shock [3H]Quinuclidinyl benzilate Muscarinic-cholinergic receptors Atropine |
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