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Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis
Affiliation:1. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China;2. Colorectal Cancer Center of Zhongshan Hospital, Fudan University, Shanghai 200032, China;3. Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA;4. Gastric Cancer Center of Zhongshan Hospital, Fudan University, Shanghai 200032, China;5. Division of Molecular and Cellular Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02138, USA;6. The Fourth Affiliated Hospital of Nanchang University, Nanchang 330003, China;7. Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA;8. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan
Abstract:
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  • Keywords:gastric neoplasm  carcinogenesis  stem cell  Cck2r  symmetric division  asymmetric division  gastrin  notch signaling  gene mutation
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