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Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism
Affiliation:1. Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany;2. Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany;3. Faculty of Biosciences, Heidelberg University, 69117 Heidelberg, Germany;4. Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Medical Center, 69120 Heidelberg, Germany;5. Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, 69120 Heidelberg, Germany;6. LOEWE Center for Cell and Gene Therapy and Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany;7. German Cancer Consortium (DKTK), 69120 Heidelberg, Germany;8. Frankfurt Cancer Institute, 60596 Frankfurt, Germany;9. Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany
Abstract:
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  • Keywords:alternative polyadenylation  APAome  3′-seq  hematopoietic stem cell  inflammation  glutaminolysis  GAC  KGA
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