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Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient
Institution:1. Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA;2. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA;3. Department of Molecular Oncology, Genentech, South San Francisco, CA 94080, USA;4. Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA 02215, USA;5. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA;6. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;7. Department of Immunology, Harvard Medical School, Boston, MA 02115, USA;8. Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA;9. Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA;10. Harvard Stem Cell Institute, Cambridge, MA 02139, USA
Abstract:
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  • Keywords:intestinal stem cell niche  mesenchyme  niche signaling gradients  single-cell RNA profiles  trophocytes  telocytes  epithelium-mesenchyme co-culture
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