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Smooth Muscle Cell Reprogramming in Aortic Aneurysms
Affiliation:1. Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA;2. Department of Surgery, Yale University School of Medicine, New Haven, CT, USA;3. Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, Guangdong Province, China;4. Computational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXiNextCODE, Cambridge, MA, USA;5. Complex Biological Systems Alliance, Medford, MA, USA;6. School of Basic Medicine, Qingdao University, Shandong, China;7. Department of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology and the Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, New York, NY, USA;8. Department of Biomedical Engineering, Yale University, New Haven, CT, USA;9. Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA;10. Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, CT, USA;11. Division of Rheumatology, Inflammation, Immunity, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;12. Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA;13. Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA;14. Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, China;15. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA;16. Genomics Laboratory, WuXiNextCODE, Shanghai, China;17. Cancer Genetics Group, WuXi NextCODE, Cambridge, MA, USA;18. Division of Genetics and Genomics, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA;19. Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA
Abstract:
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  • Keywords:aneurysm  cell fate  smooth muscle cells  TGF-beta  scRNA-seq  artificial intelligence  mesenchymal stem cell  aorta  atherosclerosis  cell reprogramming
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