A Non-invasive Method for Determining Biomechanical Properties of the Internal Carotid Artery |
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| Institution: | 1. Laboratory of Biophysics and Medical Technology, Higher Institute of Medical Technology of Tunis, Tunis Elmanar University, Tunis 1006, Tunisia;2. Laboratory of Biophysics and Medical Technology, Higher Institute of Biotechnology of Sfax, Sfax University, Sfax 3038, Tunisia;3. Department of Imaging and Biophysics, University of Picardie Jules Verne, CHU Amiens, 80054 Amiens, France;1. Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands;2. Vascular Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands;1. Chongqing Institution of Green and Intelligent Technology, Chinese Academy of Science, 266 Fangzheng Ave, Beibei District, Chongqing 400714, China;2. Mechanical Engineering, National University of Singapore, BLK EA, #04-06, Control lab 1, NUS 1 Engineering Drive 2, Singapore 117576, Singapore;1. Service de médecine nucléaire et de traitement de l’image médicale, Centre Hospitalier Universitaire d’Amiens, Amiens, France;2. Université de Picardie Jules Verne, Amiens, France;1. Department of Bioengineering, University of Washington, Seattle, Washington, USA;2. Department of Radiology, Vascular Imaging Laboratory, University of Washington, Seattle, Washington, USA;3. D. E. Strandness, Jr. Vascular Laboratory, University of Washington Medical Center, Seattle, Washington, USA;4. Department of Surgery, University of Washington, Seattle, Washington, USA;5. Retired |
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| Abstract: | ObjectivesMechanical properties of the carotid artery play an important role in the progression of arterial disease such as atherosclerosis. An early change in the mechanical properties of the arteries can be introduced as a novel risk factor for cardiovascular events. The aim of this study is to estimate, in vivo, the elastic biomechanical properties of the internal carotid wall (ICA), from the noninvasive determination of the local arterial wave speed (c).Material and methodsTo achieve this objective, c was determined from a mathematical and physical model developed in our previous work that uses the measurement of the instantaneous blood velocity at two sites by contrast magnetic resonance (PCMR), the study having been conducted on 20 healthy, young and old subjects. The determination of Young's modulus (E) requiring the measurement of the arterial radius (R) and the wall thickness (h), we first estimated the arterial compliance (C). Then from a segmentation of the PCMR image, we evaluated R and thus the elastance given by the product Eh. Finally, in front of the difficulty of measuring h, E was estimated from a statistical study on h.ResultsOur method is sensitive to a variation of the parietal elasticity as it is the case with the age. A statistical test showed that there is a very significant difference between younger and older subjects in terms of speed wave, elastance, compliance, and Young's modulus (p<0.001). Furthermore, these results, in agreement with the reference values reported in the literature, are very promising for detecting a pathological change in parietal elasticity, as is the case in atherosclerosis.ConclusionThus, the in vivo application of this technique shows its potential for clinical evaluation of arterial stiffness ICA as it is fully quantitative, non-invasive and can be performed in real time. |
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| Keywords: | Blood velocity Wave speed Arterial compliance Young's modulus Cepstral analysis |
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