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Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission
Affiliation:1. Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;2. Department of Histology and Embryology, Key Laboratory of Ministry of Education of China for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;3. Key Laboratory of Brain Research of Henan Province, Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang 453003, China;4. CAS Key Laboratory of Mental Health, Institute of Psychology, Department of Psychology, University of Chinese Academy of Sciences, Beijing 100101, China;5. Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China;6. Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226000, China
Abstract:
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  • Keywords:tau accumulation  GABAergic interneuron  adult hippocampal neurogenesis  GABA  network hyperactivation  cognitive impairment  astrogliosis
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