Influence of angiotensins (I,II & III) on prostaglandin production by minced rat renal medulla |
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Authors: | Hiroko Satoh Kyoko Matsukura Reiko Yamada Susumu Satoh |
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Affiliation: | Department of Pharmacology, Pharmaceutical Institute, Tohoku Universitym Aobayama, Sendai 980, JAPAN |
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Abstract: | Minced rat renal medulla was incubated for 30 min at 37 °C in the presence of angiotensin, I, II or III (100 ng/ml) to determine the existence of a direct stimulating effect on prostaglandin (PG) production. PGE2, PGF2α, 6-keto PGF1α and Thromboxane B2 (TXB2)_were determined by radioimmunoassay.For analysis of data variance, the results were separated according to whether the net output of PGE2 was above or below 1.5 ng PGE2 equivalent/mg tissue/30 min. Under low-output conditions, angiotensin I, II or III stimulated PGE2 production significantly (p<0.02) and tended to augment PGF2α production, while under high-output conditions no effect on PGE2 or PGF2α production was observed.Under either output condition, angiotensin I, II or III had no effect on 6-keto PGF1α and TXB2. |
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