New HLA-A2 variants defined by monoclonal antibodies and cytotoxic T lymphocytes |
| |
Authors: | Lorna J Kennedy Lesley E Wallace J Alejandro Madrigal Alan B Rickinson Julia G Bodmer |
| |
Institution: | (1) Imperial Cancer Research Fund, Lincoln's Inn Fields, P.O. Box 123, WC2A 3PX London, England;(2) Department of Cancer Studies, The Medical School, Birmingham B15 2TJ, England |
| |
Abstract: | Three HLA-A2 variants, A2-DW, A2-KC, and A2-Lee, were identified in three Chinese donors using a panel of monoclonal antibodies. A2-DW was negative with two of the ten HLA-A2 monoclonal antibodies tested, whereas A2-KC was negative with five of the ten and A-2 Lee was negative with one.Epstein-Barr virus-specific cytotoxic T cells generated from the A2-DW donor recognized and killed target cells prepared from the A2-KC donor, but did not recognize target cells from HLA-A2.1, –A2.2, or –A2.4 donors. In isoelectric focusing studies, A2-DW and A2-KC focus in identical positions more acidic than the other HLA-A2 antigens tested. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|