Mycelial morphology and metabolite production

Mycelial microorganisms are exploited extensively in the commercial production of a wide range of secondary metabolites. They can be cultured as free mycelia, as aggregated forms (pellets/flocs), or as artificially bound/entrapped cells, though problems are associated with the culture of each morphological type. Since the morphological type can strongly influence metabolite production, the methodology for inducing pellet formation, and the type of pellets produced are an important consideration for effective metabolite production.