Low-n oligomers as therapeutic targets of Alzheimer's disease |
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Authors: | Ono Kenjiro Yamada Masahito |
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Affiliation: | Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. onoken@med.kanazawa-u.ac.jp |
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Abstract: | The pathogenesis of Alzheimer's disease involves the progressive accumulation of amyloid β-protein (Aβ). Recent studies using synthetic Aβ peptides, a cell culture model, Aβ precursor protein transgenic mice models suggest that pre-fibrillar forms of Aβ are more deleterious than extracellular fibril forms. Recent findings obtained using synthetic Aβ peptides and human samples indicated that low-n oligomers (from dimers to octamers) may be proximate toxins for neuron and synapse. Here, we review the recent studies on the soluble oligomers, especially low-n oligomers in Alzheimer's disease. |
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Keywords: | Alzheimer’s disease amyloid β‐protein oligomers |
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