The action of prostaglandin E2 and F1α on myocardial ischaemia-infarction arrhythmias in the dog |
| |
Authors: | CJ Harvie GA Collins RT Miyagishima MJA Walker |
| |
Institution: | Departments of Pharmacology and Surgery Faculty of Medicine The University of British Columbia Vancouver, B. C., V6T 1W5 Canada |
| |
Abstract: | Prostaglandin E2 and F1α infusions have been tested for their ability to reduce the arrhythmias associated with occlusion of the left descending coronary artery in the anaesthetised dog. At 1 μg/kg/min both PGs reduced the incidence of premature ventricular contractions occurring during 25-min occlusions, while not reducing the incidence of ventricular fibrillation occurring on occlusion release. When infused for 5-min periods at 1 to 16 μg/kg/min, neither PGE2 nor PGF1α effectively reduced the frequency of ventricular arrhythmias occurring 24 hr after a permanent coronary occlusion. |
| |
Keywords: | Reprint requests should be directed to Dr M J A Walker Dept of Pharmacology Faculty of Medicine The University off British Columbia 2075 Wesbrook Mall Vancouver B C V6T lW5 Canada |
本文献已被 ScienceDirect 等数据库收录! |