Effect of HDL1 infusion on biliary secretion in perfused rat liver |
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| Authors: | Roberto Rivabene Alfredo Cantafora Chong Chao Yan Flavia Castellano Giovannella Bruscalupi Elena Bravo |
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| Institution: | (1) Laboratory of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita', Viale Regina Elena 299, 00161 Rome, Italy;(2) Department of Cell and Developmental Biology, University La Sapienza, Rome, Italy |
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| Abstract: | The effects of HDL1 lipoprotein infusion on biliary lipid secretion were studied in thein vitro model of rat perfused liver. A strong increase in bile flow was observed during and after lipoprotein infusion. This caused a significant rise in cholesterol, phospholipid and bile salt secretions. However, only the percentage of cholesterol increased with respect to the other bile lipids. The changes observed in the cholesterol/phospholipid molar ratio values of liver membrane subfractions (i.e., liver plasma membrane, mitochondria plus lysosomes and microsomes) isolated from the perfused rat liver after HDL1 administration were not significant. |
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| Keywords: | perfused rat liver bile secretion HDL1 cholesterol |
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