Cytokinin activity of N-phenyl-N′-(4-pyridyl)urea derivatives |
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Authors: | Soshiro Takahashi Koichi Shudo Toshihiko Okamoto Kumiko Yamada Yo Isogai |
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Institution: | 1. Laboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan;2. Department of Biology, College of General Education, University of Tokyo, Komaba, Meguro-ku, Tokyo 153, Japan |
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Abstract: | We have synthesized 35 N-phenyl-N′-(4-pyridyl)urea derivatives and tested their cytokinin activity in the tobacco callus bioassay. Among them, N-phenyl-N′- (2-chloro-4-pyridyl)urea is highly active, the optimum concentration of which is lower than 4 × 10?9 M (0.001 ppm), 3 compounds, i.e. N-(2-methylphenyl)-N′-(2-chloro-4-pyridyl)urea, N-(3-methylphenyl)-N′-(2-chloro-4-pyridyl)urea and N-(3-chlorophenyl)-N′-(2-chloro-4-pyridyl) urea are as active as N6-benzyladenine (concentration for optimum yield: 4.4 × 10?8 M or 0.01 ppm), and N-phenyl-N′-(2-methyl-4-pyridyl)urea and N-(2-chlorophenyl)-N′-(2-chloro-4-pyridyl)urea are as active as N-phenyl-N′-(4-pyridyl)urea (concentration for optimum yield: 4.7 × 10?7 M or 0.1 ppm), while the activity of the other 29 compounds are not so remarkable and 11 of them are almost or completely inactive. |
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Keywords: | Cytokinins biological activity structure-activity relationship |
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