Pseudojujubogenin,a new sapogenin from Bacopa monniera |
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Authors: | Ken-Ichi Kawai Shoji Shibata |
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Institution: | Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan |
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Abstract: | Acid hydrolysis of bacoside A, a saponin of Bacopa monniera, afforded ebelin lactone and bacogenin-A1, while Smith-de Mayo degradation of bacoside A yielded jujubogenin and pseudojujubogenin as sapogenins. The structure of pseudojujubogenin except the absolute configurations at C-20 and C-22 was established by chemical and spectroscopic investigations. Bacoside A was separated by droplet counter-current chromatography into two fractions, A1 and A2, which, however, are mixtures, since they both afforded two sapogenins, in different ratios by Smith-de Mayo degradation. |
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Keywords: | Scrophulariaceae bacoside A jujubogenin ebelin lactone pseudojujubogenin |
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