Lung delivery of nanoliposomal salbutamol sulfate dry powder inhalation for facilitated asthma therapy |
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Authors: | Sandip Honmane Ashok Hajare Harinath More Riyaz Ali M Osmani Sachin Salunkhe |
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Institution: | 1. Department of Pharmaceutics, Annasaheb Dange College of B. Pharmacy, Shivaji University, Kolhapur, India;2. Bharati Vidyapeeth’s College of Pharmacy, Shivaji University, Kolhapur, India;3. sandiphonmane@gmail.com;5. Bharati Vidyapeeth’s College of Pharmacy, Shivaji University, Kolhapur, India;6. Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysuru, India |
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Abstract: | AbstractThe motive behind present work was to discover a solution for overcoming the problems allied with a deprived oral bioavailability of salbutamol sulfate (SS) due to its first pass hepatic metabolism, shorter half-life, and systemic toxicity at high doses. Pulmonary delivery provides an alternative route of administration to avoid hepatic metabolism of SS, moreover facilitated diffusion and prolonged retention can be achieved by incorporation into liposomes. Liposomes were prepared by thin film hydration technique using 32 full factorial design and formulation was optimized based on the vesicle size and percent drug entrapment (PDE) of liposomes. Optimized liposomal formulation exhibited an average size of about 167.2?±?0.170?nm, with 80.68?±?0.74% drug entrapment, and 9.74?±?1.10?mV zeta potential. The liposomal dispersion was then spray dried and further characterized for in-vitro aerosol performance using Andersen Cascade Impactor. Optimized liposomal formulation revealed prolonged in-vitro drug release of more than 90% up to 14?h following Higuchi’s controlled release model. Thus, the proposed new-fangled liposomal formulation would be a propitious alternative to conventional therapy for efficient and methodical treatment of asthma and alike respiratory ailments. |
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Keywords: | Asthma drug delivery dry powder inhaler factorial design liposomes salbutamol sulfate |
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