Linkage of Patr-AL to Patr-A and-B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes) |
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| Authors: | Ron Geller Erin J. Adams Lisbeth A. Guethlein Ann-Margaret Little Alejandro J. Madrigal Peter Parham |
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| Affiliation: | Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305-5126, USA. |
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| Abstract: | Patr-AL is a recently described gene found only in the common chimpanzee, but closely related in structure to the highly polymorphic Patr-A and HLA-A genes of the chimpanzee and human MHCs, respectively. Unlike Patr-A and HLA-A, the Patr-AL gene has little polymorphism and is not fixed in the chimpanzee genome. To determine whether Patr-AL is located in the MHC or elsewhere, we compared segregation of the Patr-AL gene with segregation of Patr-A and - B alleles in chimpanzee families. The results demonstrate that Patr-AL is an MHC class I gene present on different MHC haplotypes as defined by their combination of Patr-A and B alleles. |
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