Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines |
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Authors: | Alvaro J González Li Liao |
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Institution: | 1.Department of Computer and Information Sciences,University of Delaware,Newark,USA |
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Abstract: | Background Protein-protein interaction (PPI) plays essential roles in cellular functions. The cost, time and other limitations associated
with the current experimental methods have motivated the development of computational methods for predicting PPIs. As protein
interactions generally occur via domains instead of the whole molecules, predicting domain-domain interaction (DDI) is an
important step toward PPI prediction. Computational methods developed so far have utilized information from various sources
at different levels, from primary sequences, to molecular structures, to evolutionary profiles. |
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Keywords: | |
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