Ageing of the spermatogenesis system |
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Authors: | S T Zahidov A N Hohlov E A Malolina A Yu Kulibin T L Marshak |
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Institution: | (1) Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, San Diego, CA 92037, USA |
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Abstract: | This review summarizes the data characterizing the effect of ageing on the development of male germ cells and their hereditary
structures. We have studied causes of spermatogenesis reduction at late stages of ontogenesis. We have focused on age-specific
changes of the structural—functional integrity of stem spermatogonial cells and their microenvironment (niche). We also examined
several unique and specific features of the spermatogenic system in senescence-accelerated mutant mice (SAM), with accelerated
ageing. |
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Keywords: | |
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