Small variable segments constitute a major type of diversity of bacterial genomes at the species level |
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| Authors: | Fabrice Touzain Erick Denamur Claudine Médigue Valérie Barbe Meriem El Karoui Marie-Agnès Petit |
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| Affiliation: | 1.INRA, UMR1319, Micalis,Jouy en Josas,France;2.INSERM U722 and Université Paris 7, Faculté de Médecine,Paris,France;3.CNRS-UMR 8030 & CEA/IG/Genoscope, Laboratoire d'Analyses Bioinformatiques en Génomique et Métabolisme (LABGeM),Evry,France;4.CEA, Institut de Génomique, Genoscope,Evry,France |
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| Abstract: | Background Analysis of large scale diversity in bacterial genomes has mainly focused on elements such as pathogenicity islands, or more generally, genomic islands. These comprise numerous genes and confer important phenotypes, which are present or absent depending on strains. We report that despite this widely accepted notion, most diversity at the species level is composed of much smaller DNA segments, 20 to 500 bp in size, which we call microdiversity. |
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