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Neuropeptide Y (NPY) functional group mimetics: design, synthesis, and characterization as NPY receptor antagonists |
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| Authors: | Michael B. Doughty Shao Song Chu Gregory A. Misse Richard Tessel |
| Affiliation: | a Departments of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045-2506, U.S.A. b Departments of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 6645-2506, U.S.A. |
| Abstract: | N,N′-bis-[2-N-(O-2,6-dichlorobenzyl-L-tyrosyl)aminoethylguanyl]cystamine 3 and N,N′-bis-[2-N-(O-2,6-dichlorobenzyl-L-tyrosyl)aminoethyl]-1,6-hexanediguanidine 4 have been designed as neuropeptide Y (NPY) functional group mimetics. Both 3 and 4 displace N-[propionyl-3H]-NPY from rat brain binding sites, and are NPY receptor antagonists in rat femoral artery ring segments. |
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