Mixed-ligand complexes of platinum(II) as curing agents for pBR322 and pBR329 (ColE1) plasmids in Escherichia coli |
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| Authors: | V V Lakshmi P Sridhar B T Khan H Polasa |
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| Affiliation: | I. Department of Microbiology, Osmania University, Andhra Pradesh, India. |
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| Abstract: | The mixed-ligand complexes of platinum(II) [Pt(Gly)(uracil)Cl2].H2O and [Pt(His)(adenine)]-Cl.2H2O eliminated multicopy plasmids with the ColE1 origin of replication in Escherichia coli with 100% frequency. However, plasmids of the IncF1, H1 and X groups were totally refractory to these agents under similar conditions. |
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