Two Distinct Pathways for Targeting Proteins from the Cytoplasm to the Vacuole/Lysosome |
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| Authors: | Misuzu Baba Masako Osumi Sidney V. Scott Daniel J. Klionsky Yoshinori Ohsumi |
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| Affiliation: | *Department of Cell Biology, National Institute for Basic Biology, Okazaki 444, Japan; ‡Department of Chemical and Biological Sciences, Faculty of Science, Japan Women''s University, Mejirodai, Tokyo 112, Japan; and §Section of Microbiology, University of California, Davis, California 95616 |
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| Abstract: | Stress conditions lead to a variety of physiological responses at the cellular level. Autophagy is an essential process used by animal, plant, and fungal cells that allows for both recycling of macromolecular constituents under conditions of nutrient limitation and remodeling the intracellular structure for cell differentiation. To elucidate the molecular basis of autophagic protein transport to the vacuole/lysosome, we have undertaken a morphological and biochemical analysis of this pathway in yeast. |
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