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Studies on lipid peroxidation in rat liver by copper deficiency

Affiliation:	1. Research Center of Laser Fusion, CAEP, Mianyang, 621900, PR China;2. School of Chemistry & Chemical Engineering, Mianyang Teachers’ College, Mianyang, 621000, PR China;1. Molecular Immunology Section, Laboratory of Immunology, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD 20892, USA;2. Laboratory of Immunology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China

Abstract:	1.1. Copper deficiency in rats results in a 2-fold increase in the level of lipid hydroperoxides in liver mitochondria and microsomes. 2.2. The specific activity of cupro-zinc Superoxide dismutase decreases up to 30% while that of the mangano-enzyme is not changed. 3.3. Glutathione peroxidase activity as well as catalase activity are suppressed in both cytosol and mitochondrial fractions from copper-deficient rat liver.

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