Impaired microtubule assembly in brain from zinc-deficient pigs and rats |
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Affiliation: | Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, Scotland, U.K. |
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Abstract: | - 1.1. Microtubule reassembly was studied in brain extracts from pigs and rats deficient in zinc and from zinc-supplemented controls. Tubulin in extracts from zinc-deficient animals showed an impaired ability to repolymerize compared with extracts from control animals.
- 2.2. Crude microtubule protein isolated from zinc-deficient rat brain contained less free SH groups than that isolated from zinc-supplemented animals.
- 3.3. It is concluded that variation in zinc concentration close to the physiological range can influence microtubule assembly, and that zinc may have some function in microtubule polymerization in vivo.
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