Structure of 1-acyl lysophosphatidylcholine and fatty acid complex in bilayers |
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| Affiliation: | 1. College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China;2. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, PR China;1. Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Munich, Germany;2. Department of Chemistry, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark;1. Department of Physics, Hashemite University, Zarqa, Jordan;2. Department of Physics, University of Tabuk, Tabuk, Saudi Arabia;3. Department of Chemistry, Hashemite University, Zarqa, Jordan;1. Department of Otorhinolaryngology, Children''s Hospital of Chongqing Medical University, Pediatric Research Institute of Chongqing Medical University, National Key Disciplinary Areas of Pediatrics, Ministry of Education, Chongqing, 400014, China;2. Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China;3. Eye Research Institute, Oakland University, Rochester, Michigan 48309;4. Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160-7421 |
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| Abstract: | The phase transition characteristics of bilayers formed in a codispersion of 1-acyl lysophosphatidylcholine and a fatty acid depend on the chain length of both the components and on the pH of the aqueous medium. Incorporation of cholesterol as a third component abolishes the transition. It is suggested that acyl chain interactions between fatty acid and 1-acyl lysophosphatidylcholine molecules in their aqueous codispersions are maximized by close-packing such that the acyl chains of both molecules are aligned parallel to each other and the carboxyl group is located in the vicinity of the 2-hydroxyl group of lysophosphatidylcholine. The shape and size of a functional dimer thus formed are similar but not identical to those of 1,2-diacyl phosphatidylcholine. Several predictions arising from this suggestion, including phase separation in codispersions of fatty acid + 1-acyl lysophosphatidylcholine + diacyl phosphatidylcholine, are experimentally confirmed. |
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