The role of Zn2+ in pyridoxal phosphate mediated regulation of glutamic acid decarboxylase in brain |
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| Affiliation: | 1. Laboratory of Marine Biotechnology, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile;2. Laboratory of Coastal Environmental Research, Center of Advanced Studies, University of Playa Ancha, Viña del Mar, Chile |
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| Abstract: | - 1.1. γ-Aminobutyric acid, a major inhibitory neurotransmitter in the CNS, is synthesized by glutamic acid decarboxylase which demonstrates an absolute requirement for pyridoxal phosphate.
- 2.2. At physiological concentrations, zinc stimulates the activity of pyridoxal kinase, enhancing the formation of pyridoxal phosphate, which in turn stimulates the activity of glutamic acid decarboxylase.
- 3.3. At pharmacological concentrations, zinc inhibits the activity of glutamic acid decarboxylase without inhibiting pyridoxal kinase.
- 4.4. These results suggest that zinc may play a role in pyridoxal phosphate-mediated regulation of glutamic acid decarboxylase.
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