Pharmacokinetic curve fitting and parameter determination by non-linear,iterative least squares regression analysis using a programmed minicalculator |
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| Affiliation: | 2. Birmingham Veterans Administration Medical Center, Birmingham, AL;1. Division of Vascular Surgery and Endovascular Therapy, The Johns Hopkins Medical Institutions, Baltimore, MD;2. Division of Vascular Surgery, University of Colorado Anschutz School of Medicine, Aurora, CO;3. Division of Vascular Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA;1. Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan;2. Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan;3. Department of Gastroenterological Surgery I, Hokkaido University Hospital, Sapporo, Hokkaido, Japan;4. Division of Organ Transplantation, Central Clinical Facilities, Hokkaido University Hospital, Sapporo, Hokkaido, Japan;1. Thoracic Department, Istituto Nazionale Tumori, IRCCS – Fondazione G. Pascale, Via M. Semmola, 80131, Napoli, Italy;2. Clinical Trials Unit, Istituto Nazionale Tumori, IRCCS – Fondazione G. Pascale, Via M. Semmola, 80131, Napoli, Italy;3. Medical Oncology, A.O. San Giuseppe Moscati, Contrada Amoretta,Città Ospedaliera, 83100, Avellino, Italy;4. Medical Oncology, Ospedale S. Paolo, Via A. di Rundinì, 20142, Milano, Italy;5. Gruppo Italiano di Oncologia Geriatrica (GIOGER), Italy;6. Department of Oncology/Hematology, Ospedale Guglielmo da Saliceto, Via Taverna Giuseppe, 29121, Piacenza, Italy;7. Medical Oncology II, Istituto Oncologico Veneto, IRCCS, Via Gattamelata, 35128, Padova, Italy;8. Medical Oncology, Ospedale L. Sacco, Polo Universitario, Via G.B. Grassi, 20157, Milano, Italy;9. Medical Oncology, AO Vito Fazzi, Piazza F. Muratore, 73100, Lecce, Italy;10. Medical Oncology, Ospedale Senatore Antonio Perrino, S.S.7 per Mesagne, 72100, Brindisi, Italy;11. Medical Oncology and Hematology, Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Via Pansini 5, 80131, Napoli, Italy;12. Medical Oncology, Istituto Romagnolo per lo Studio e la Cura dei Tumori, IRCCS, Via Piero Maroncelli, 47014, Meldola, FC, Italy;13. Medical Oncology, AO San Carlo, Via Potito Petrone, 85100, Potenza, Italy;14. Medical Oncology and Hematology, Mirano ULSS 3, Serenissima Regione Veneto, Via Sartor 4, 30174, Mirano, VE, Italy;15. Medical Oncology, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131, Napoli, Italy;p. Medical Oncology, Ospedale Ramazzini di Carpi e Ospedale di Mirandola, Via G. Molinari, 41012, Carpi, MO, Italy;q. Medical Oncology, Ospedale San Gerardo, Via G.B. Pergolesi, 20900, Monza, Italy;r. Medical Oncology, Casa di Cura La Maddalena Università di Palermo, Via S. Lorenzo, 90146, Palermo, Italy;s. Medical Oncology, Istituti Clinici Scientifici Maugeri, Via S. Maugeri, 27100, Pavia, Italy;t. Medical Oncology, Ospedale Villa Scassi, ASL 3 Genovese, Corso O. Scassi, 16121, Genova Sampierdarena, Italy;u. Medical Statistics, Università degli Studi della Campania Luigi Vanvitelli, Via L. Armanni, 80128, Napoli, Italy;1. Department of Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt;2. Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt;3. Department of Anatomy, Faculty of Medicine, Cairo University, Cairo, Egypt;1. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA;2. Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA |
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| Abstract: | A pharmacokinetic non-linear, iterative least-squares program for the minicalculator TI-59 with adapted printer is described. The program utilizes the Gauss-Newton gradient method in an iterative, non-linear regression analysis of up to 18 data pairs. Single-dose plasma concentration data of 5-hydroxytryptophan, theophylline and prednisolone were comparatively analysed using both the described program (called NONTI-59) and Metzlers well-established digital computer program NONLIN. |
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