Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. |
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| Authors: | N Dyson R Bernards S H Friend L R Gooding J A Hassell E O Major J M Pipas T Vandyke and E Harlow |
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| Institution: | Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724. |
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| Abstract: | Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution. |
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