Helicobacter pylori and gastric autoimmunity |
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| Authors: | D'Elios Mario Milco Bergman Mathijs P Amedei Amedeo Appelmelk Ben J Del Prete Gianfranco |
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| Institution: | Department of Internal Medicine, University of Florence, Viale Morgagni, 85-50134 Florence, Italy. delios@unifi.it |
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| Abstract: | Host specific T-cell response is critical for the outcome of Helicobacter pylori infection. In genetically susceptible individuals, H. pylori can activate gastric CD4+ Th1 cells that recognize cross-reactive epitopes shared by H. pylori proteins and self H+, K+-ATPase, leading to gastric autoimmunity via molecular mimicry. |
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