Conjugation of functionalized SPIONs with transferrin for targeting and imaging brain glial tumors in rat model |
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Authors: | Jiang Weili Xie Hui Ghoorah Devina Shang Yalei Shi Haojun Liu Fang Yang Xiangliang Xu Haibo |
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Affiliation: | Radiology Department of Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. |
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Abstract: | Currently, effective and specific diagnostic imaging of brain glioma is a major challenge. Nanomedicine plays an essential role by delivering the contrast agent in a targeted manner to specific tumor cells, leading to improvement in accurate diagnosis by good visualization and specific demonstration of tumor cells. This study investigated the preparation and characterization of a targeted MR contrast agent, transferrin-conjugated superparamagnetic iron oxide nanoparticles (Tf-SPIONs), for brain glioma detection. MR imaging showed the obvious contrast change of brain glioma before and after administration of Tf-SPIONs in C6 glioma rat model in vivo on T2 weighted imaging. Significant contrast enhancement of brain glioma could still be clearly seen even 48 h post injection, due to the retention of Tf-SPIONs in cytoplasm of tumor cells which was proved by Prussian blue staining. Thus, these results suggest that Tf-SPIONs could be a potential targeting MR contrast agent for the brain glioma. |
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