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Estimating the Recombination frequency for the PTC-Kell linkage |
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| Authors: | Anne-Spence M Falk Catherine T Neiswanger Katherine Leigh Field L Marazita Mary L Allen F H Siervogel Roger M Roche Alex F Crandall Barbara F Sparkes Robert S |
| Institution: | (1) Division of Medical Genetics, Department of Psychiatry, Medicine, Pediatrics and Biomathematics, UCLA School of Medicine, Los Angeles, USA;(2) Lindsley F. Kimball Research Institute of the New York Blood Center, New York, USA;(3) Medical Genetics Clinic, Alberta Children's Hospital, Calgary, Canada;(4) Department of Pediatrics, Fels Research Institute, Wright State University, Yellow Springs, OH, USA;(5) MR Unit/NPI, 760 Westwood Plaza, 90024 Los Angeles, CA, USA |
| Abstract: | Summary Two data sets are analyzed for linkage between the PTC and Kell blood group loci. The original report of close linkage for these loci was that of Conneally et al. (1976), where the maximum likelihood estimate of  was 0.05. These two new data sets give a combined maximum likelihood estimate of
m=f
=0.28. Estimating the recombination frequency for the sexes separately gave
m
=0.29,
f
=0.23. The combined maximum likelihood estimate over all published data sets including this report is
m=f
=0.14,
max=8.94. There is statistically significant evidence of heterogeneity among the published studies. |
| Keywords: | |
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